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Approved EGFR and PARP-1 inhibitors.

Journal: ACS Omega

Article Title: Synthesis of New Bioactive Indolyl-1,2,4-Triazole Hybrids As Dual Inhibitors for EGFR/PARP-1 Targeting Breast and Liver Cancer Cells

doi: 10.1021/acsomega.2c06531

Figure Lengend Snippet: Approved EGFR and PARP-1 inhibitors.

Article Snippet: To assess the inhibitory potency of compound 13b against target inhibition of PARP-1 and EGFR, we used PARP-1 (Bioscience, Cat No. 80580, CA, USA) and EGFR (ADP-GloTM kinase assay, Cat No. V9261, Promega, USA).

Techniques:

Indolyl-triazole hybrids showing EGFR and PARP-1 inhibition activity.

Journal: ACS Omega

Article Title: Synthesis of New Bioactive Indolyl-1,2,4-Triazole Hybrids As Dual Inhibitors for EGFR/PARP-1 Targeting Breast and Liver Cancer Cells

doi: 10.1021/acsomega.2c06531

Figure Lengend Snippet: Indolyl-triazole hybrids showing EGFR and PARP-1 inhibition activity.

Article Snippet: To assess the inhibitory potency of compound 13b against target inhibition of PARP-1 and EGFR, we used PARP-1 (Bioscience, Cat No. 80580, CA, USA) and EGFR (ADP-GloTM kinase assay, Cat No. V9261, Promega, USA).

Techniques: Inhibition, Activity Assay

Highlighted pharmacophoric regions with the previously reported triazole-based PARP-1 and EGFR target inhibition.

Journal: ACS Omega

Article Title: Synthesis of New Bioactive Indolyl-1,2,4-Triazole Hybrids As Dual Inhibitors for EGFR/PARP-1 Targeting Breast and Liver Cancer Cells

doi: 10.1021/acsomega.2c06531

Figure Lengend Snippet: Highlighted pharmacophoric regions with the previously reported triazole-based PARP-1 and EGFR target inhibition.

Article Snippet: To assess the inhibitory potency of compound 13b against target inhibition of PARP-1 and EGFR, we used PARP-1 (Bioscience, Cat No. 80580, CA, USA) and EGFR (ADP-GloTM kinase assay, Cat No. V9261, Promega, USA).

Techniques: Inhibition

EGFR/PARP Target Inhibition of Compounds 12b , 13a , and 13b

Journal: ACS Omega

Article Title: Synthesis of New Bioactive Indolyl-1,2,4-Triazole Hybrids As Dual Inhibitors for EGFR/PARP-1 Targeting Breast and Liver Cancer Cells

doi: 10.1021/acsomega.2c06531

Figure Lengend Snippet: EGFR/PARP Target Inhibition of Compounds 12b , 13a , and 13b

Article Snippet: To assess the inhibitory potency of compound 13b against target inhibition of PARP-1 and EGFR, we used PARP-1 (Bioscience, Cat No. 80580, CA, USA) and EGFR (ADP-GloTM kinase assay, Cat No. V9261, Promega, USA).

Techniques: Inhibition

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Journal: ACS Omega

Article Title: Synthesis of New Bioactive Indolyl-1,2,4-Triazole Hybrids As Dual Inhibitors for EGFR/PARP-1 Targeting Breast and Liver Cancer Cells

doi: 10.1021/acsomega.2c06531

Figure Lengend Snippet: Ligand–Receptor Interactions of the Docked Compound 13b with Binding Energies (kcal/mol) inside the PARP-1 and EGFR Proteins a

Article Snippet: To assess the inhibitory potency of compound 13b against target inhibition of PARP-1 and EGFR, we used PARP-1 (Bioscience, Cat No. 80580, CA, USA) and EGFR (ADP-GloTM kinase assay, Cat No. V9261, Promega, USA).

Techniques: Binding Assay